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Your body performs that maintenance when you are young. The damage repair approach to treating aging suggests that if we remove the fundamental differences bet
by reasonattlm 12y ago
Your body performs that maintenance when you are young.
The damage repair approach to treating aging suggests that if we remove the fundamental differences between old and young tissue, then the body will continue to maintain itself as it does when it is young. There are not all that many types of fundamental damage.
So this doesn't require maintaining the whole system; it requires removing the spanners in the works. These spanners are well known and well characterized. For example, cross-links in the extracellular matrix that degrade blood vessel elasticity, that causes hypertension, cardiac remodeling, and microstrokes, and so on. Break down the cross-links with designed drugs (and deal a few other items that also contribute to stiffening) before the point of serious remodeling and all of that goes away, because it is the stiffening that drives this dsyfunction. There are a number of other items that have similar roles, but not so many that it is unfeasible to think of producing effective therapies on a time scale of the next two decades.
Think of damage of this sort as rust in a fantastically complex metal sculpture. You don't have to understand the sculpture, just how to rust-proof it, and how to remove the existing rust. Rust is simple, and the complexity of the sculpture doesn't much matter when it comes to how you approach rust-proofing and removal.
- p1esk 12y agoCancer is simpler than aging. We understand cancer better than aging. Yet after many billions of dollars and billions of hours of research, we still cannot "cure" cancer. A huge number of people die from it every year.