The difference between psychosomatic and organic is the etiology of the illness -- whether it is mainly caused/perpetuated by stress/emotions or similar. Certa

The difference between psychosomatic and organic is the etiology of the illness -- whether it is mainly caused/perpetuated by stress/emotions or similar. Certainly, it's possible for the brain and body to influence each other. Any severe infection will induce "sickness behaviour" for example, causing symptoms like fatigue and depression -- very similar to CFS in fact. However there is quite significant evidence that is caused by a dysregulation of the stress system, and not really much if any evidence showing an infectious etiology. Pretty much all the pathophysiology is consistent with a stress related illness, including this interferon-gamma biomarker.