In other forums, I have proposed to use DNP as a treatment for my condition (mitochondrial myopathy) and I am happy to see that there are lines of research look

In other forums, I have proposed to use DNP as a treatment for my condition (mitochondrial myopathy) and I am happy to see that there are lines of research looking into this. Using DNP to treat disease is scary with a reason; due to its narrow therapeutic index[1], it is very easy to overdose. However, its mechanism of action is clearly understood[2]: It decouples the electron transport chain, causing a signalling cascade that results in the activation of mitochondrial biogenesis. In this particular case, it is sad to see that we need a pill for everything; in many cases, T2D is easily controlled [3], even reversed, with aerobic exercise (note also that the mitochondrial biogenesis pathway is activated with exercise[4]) [1] http://en.wikipedia.org/wiki/Therapeutic_index http://en.wikipedia.org/wiki/Therapeutic_index [2] http://link.springer.com/article/10.1007/BF01868062#page-1 http://link.springer.com/article/10.1007/BF01868062#page-1 [3] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773368/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773368/ [4] http://advances.nutrition.org/content/4/6/657.long http://advances.nutrition.org/content/4/6/657.long