Interestingly, one variant of hereditary dwarfism that is present in a small group of people, Laron syndrome [1], is a good illustration to show that methods of

Interestingly, one variant of hereditary dwarfism that is present in a small group of people, Laron syndrome [1], is a good illustration to show that methods of altering the operation of metabolism to extend healthy life in short-lived mammals should not be expected to produce anywhere near the same gains in long-lived humans. The longest lived engineered mice are those with disruptions to growth hormone or its receptor, and Laron syndrome is much the same thing. The mice live as much as 70% longer, but people with Laron syndrome don't seem to be any longer lived than the rest of us, though it is possible based on the data gathered to date that they are somewhat more resistant to cancer and diabetes. [1]: https://en.wikipedia.org/wiki/Laron_syndrome https://en.wikipedia.org/wiki/Laron_syndrome