Have you tried Twitter Bootstrap? It follows the "mobile first" philosophy that you're after, and it's also quite easy to disable responsiveness entirely, if ne

Have you tried Twitter Bootstrap? It follows the "mobile first" philosophy that you're after, and it's also quite easy to disable responsiveness entirely, if needed. I'm mainly a back-end developer and I (passionately) hate doing front-end work, yet with Bootstrap I feel like it is taking a huge load off my shoulders. AFAIK it does a great job at supporting the various browsers, widths, orientation and so on, also comes with some boilerplate JS for stuff like highlighting a mandatory form field, handling modals, buttons etc...