The graph chosen here, the ratio of a toxic does to a typical dose, is a poor proxy for actual risk. For instance, cocaine has a relatively high risk of causing

The graph chosen here, the ratio of a toxic does to a typical dose, is a poor proxy for actual risk. For instance, cocaine has a relatively high risk of causing heart problems at "non-toxic" doses. GHB has a low ratio of deadly to recreational (though not so low that it's unmanageable,) yet is one of the safest recreational drugs. This is similar to the British health leader's announcement that MDMA was safer than alcohol, entirely based on how much likely someone was to die, as opposed to other potential negative effects like neurotoxicity. I'm a support of full drug legalization, and agree that most drugs are far less harmful when taken properly than alcohol. It would be great to see less obtuse statistical analysis of risk.