I'm sorry for the broadness of my question. When writing it down I was thinking about utility softwares for sharing files or for taking notes that nowadays hav

I'm sorry for the broadness of my question. When writing it down I was thinking about utility softwares for sharing files or for taking notes that nowadays have usually both client-side applications and web-based ones. Of course specific control software for manufacturing or computation-heavy programs where not in my mind. Regarding File System access, this is one of the biggest advantages I see in a client-side application. Though, we are going towards the sandboxed apps way, and we may lose control over FS even on the client side. HTML may also eventually get more access to FS in future iterations. I do agree also that HTML+CSS+JS is somewhat painful compared to the desktop UI toolkits.