Another factor often forgotten is that HRT very poorly mimics the natural testosterone fluctuations in the body. Testosterone fluctuates on a regular daily cyc

Another factor often forgotten is that HRT very poorly mimics the natural testosterone fluctuations in the body. Testosterone fluctuates on a regular daily cycle, the reason for which is not known. Therefore it is not reproduced in treatment. The assumption is "we don't know why, so it mustn't be important". Also the typical cycle of quarterly shots of T undecanoate or other similar regimes produce unphysiological fluctations from one injection to the next of over 110%. The patient goes from very high levels of test (close to 1000ug/dl) to very marginal levels (around 350). Perhaps because of this, side effects from taking T supplements, such as hematocrit (excess red blood cell volume) are far greater with supplements than with those experiencing the same level of T from endogenous sources.