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Fascinating research. I just hope the same mistakes aren't repeated and a really rigorous and robust effort is made to find what sorts of applications these sub

Fascinating research. I just hope the same mistakes aren't repeated and a really rigorous and robust effort is made to find what sorts of applications these substances can be used for. I'm reminded of LSD microdosing by scientists to improve innovation that had been done before, but I am unaware of to what degree it really bore any viable fruit.

kahoon 12y ago
http://en.wikipedia.org/wiki/Psychedelics_in_problem-solving_experiment#Results http://en.wikipedia.org/wiki/Psychedelics_in_problem-solving... Solutions obtained in the experiment include:[3][5][6] - a new approach to the design of a vibratory microtome - a commercial building design, accepted by the client - space probe experiments devised to measure solar properties - design of a linear electron accelerator beam-steering device - engineering improvement to a magnetic tape recorder - a chair design, modeled and accepted by the manufacturer - a letterhead design, approved by the customer - a mathematical theorem regarding NOR gate circuits - completion of a furniture-line design - a new conceptual model of a photon, which was found useful - design of a private dwelling, approved by the client - insights regarding how to use interferometry in medical diagnosis application sensing heat distribution in the human body
a8da6b0c91d 12y ago
Allegedly one of the forces working against LSD research is the popular narrative about how SSRIs work: the idea that higher serotonin is good. The primary mechanism of LSD appears to be serotonin agonism. In a hand-wavy way you can argue that elevated serotonin numbs a mammal and dulls perception of the world, and that reducing it makes thought and senses more vivid. An LSD trip is arguably the experience of removing the filters. The idea that SSRIs even boost serotonin levels is probably wrong. The mechanisms of action are more complicated than that. But the serotonin narrative is well established and in use by a multi-billion dollar industry.
- task_queue 12y ago
  Agonism isn't antagonism. Though, some of the first and newer antidepressants are antagonists or mixed agonist/antagonist. Some forgo significant SERT binding altogether. Their simple narrative wouldn't have been torn apart by LSD research anymore than the industries other offerings.

kahoon 12y ago

http://en.wikipedia.org/wiki/Psychedelics_in_problem-solving_experiment#Results http://en.wikipedia.org/wiki/Psychedelics_in_problem-solving... Solutions obtained in the experiment include:[3][5][6] - a new approach to the design of a vibratory microtome - a commercial building design, accepted by the client - space probe experiments devised to measure solar properties - design of a linear electron accelerator beam-steering device - engineering improvement to a magnetic tape recorder - a chair design, modeled and accepted by the manufacturer - a letterhead design, approved by the customer - a mathematical theorem regarding NOR gate circuits - completion of a furniture-line design - a new conceptual model of a photon, which was found useful - design of a private dwelling, approved by the client - insights regarding how to use interferometry in medical diagnosis application sensing heat distribution in the human body

a8da6b0c91d 12y ago

Allegedly one of the forces working against LSD research is the popular narrative about how SSRIs work: the idea that higher serotonin is good. The primary mechanism of LSD appears to be serotonin agonism. In a hand-wavy way you can argue that elevated serotonin numbs a mammal and dulls perception of the world, and that reducing it makes thought and senses more vivid. An LSD trip is arguably the experience of removing the filters. The idea that SSRIs even boost serotonin levels is probably wrong. The mechanisms of action are more complicated than that. But the serotonin narrative is well established and in use by a multi-billion dollar industry.

task_queue 12y ago
Agonism isn't antagonism. Though, some of the first and newer antidepressants are antagonists or mixed agonist/antagonist. Some forgo significant SERT binding altogether. Their simple narrative wouldn't have been torn apart by LSD research anymore than the industries other offerings.