I manage a large isomorphic app (m.trulia.com), and it's wonderful for our specific use case: Mobile website offering an app-like UI. All our node layer does i

I manage a large isomorphic app (m.trulia.com), and it's wonderful for our specific use case: Mobile website offering an app-like UI. All our node layer does is route requests, make API calls to our non-javascript business logic / data layer, and render the backbone app into HTML on the initial request. So there's a nice clean separation of UI and business logic, in different repos even. But as other posters have mentioned, it's only right for you if a single page app experience is right for you AND site performance (and SEO) is really important.