Obviously, when comparing different methods of computation with negligible cache/memory footprint, I'd run it on hot caches to maximize the visible effect on th

Obviously, when comparing different methods of computation with negligible cache/memory footprint, I'd run it on hot caches to maximize the visible effect on the implementation. File here was about 1.5 GB on a 4GB RAM machine, and I repeated each test to have a stable duration for each. Would I have tested, say, different patterns of data access (reading files sequentially, parallel read from multiple disks/partitions), of course I would have made sure that either caches are cleared (/proc/sys/vm/drop_caches), datasets will exceed memory, and actual CPU load of the algorithm is according to the real-world-usage scenario (pure read() throughput is meaningless when CPU is bogged, and L1-3 caches swamped by actual algorithmic work). Re: your additional tests: Interesting, what python-version and size of files are you running it on?