3 ms·

> except that the serotonin model of depression has been disproven without a shadow of a doubt Serious? Man, that would probably piss a lot of people off. Is t

• Havoc 12y ago
  Given that it's a YouTube link I'm going to go with not peer-reviewed.
  • shkkmo 12y ago
    ...and you would be wrong. The papers he references in his talk are peer reviewed. The lecture, of course, is not :)
• derefr 12y ago
  SSRIs are, across many meta-analyses, pretty much exactly as effective as placebo—and, insofar as placebo itself is pretty effective, it's been found to be because structured attention and the ritual of consuming medicine are themselves somewhat effective treatments for depression. Other lines of counter-evidence exist, including that there are drugs that stimulate other neurotransmitters that help with depression, that there are drugs that lower serotonin that help with depression, that there's no coherent explanation for how serotonin's main effect (neurogenesis) would actually lead to modulating depression, etc. Academia seems focused on the role of the NMDA receptor now, but it'll likely be another red herring too. I recommend reading http://slatestarcodex.com/2015/01/05/chronic-psychitis/ http://slatestarcodex.com/2015/01/05/chronic-psychitis/ just to get clear on how much of what we're doing is repeatedly picking correlated symptoms and assuming they're the cause.