It's almost certainly a bug in a build script somewhere, and they're dynamically linking against something via the wrong name. I once linked against Quicktime.f

It's almost certainly a bug in a build script somewhere, and they're dynamically linking against something via the wrong name. I once linked against Quicktime.framework, and it worked on everything but my case-sensitive Mac. QuickTime.framework worked everywhere. So your Adobe example is flawed. They should be testing on case-sensitive volumes, but the vast majority of normal users don't want a file named README and readme in the same directory, and enforcing that invariant seems reasonable to me.