It is not self-destruction, I think, it is rather "never evolved/selected for a long run". Everything "important" is supposed to happen in youth, at peak and th

It is not self-destruction, I think, it is rather "never evolved/selected for a long run". Everything "important" is supposed to happen in youth, at peak and then "doesn't matter". It is rather "stopping investing in repair" rather than "intentional self-destruction". But I think there is no single "marker/indicator" for this. So, they could keep regeneration of some specific kind of cells in a lab animal, by manipulating some hormone, but it doesn't affect the other parallel processes in different kinds of cells.