I didn't play too many 2-player dominion games, but I enjoyed the 3 or 4-player games more. For both types, card sets with little interaction usually have one

I didn't play too many 2-player dominion games, but I enjoyed the 3 or 4-player games more. For both types, card sets with little interaction usually have one or two good strategies, and luck plays a large-ish role in whether you or your opponent(s) can execute the strategy faster. Card sets with more interaction are IMO strategically more interesting with more than one opponent. Usually, everyone will focus on keeping the strongest player from winning, who in turn gains less from further weakening a single opponent already weaker than him. In 2-player games, the stronger player can just lash out at the only other opponent, which directly increases his chance of winning. So the chance of turning a game around after half the time played is much slimmer in a 2-player game than in a 4-player game, from my experience. Anyway, Dominion is a great game that packs a lot of strategical depth in a rather short playing time!