> But the forcing factor in the weight system is net caloric balance, which is also the easiest to control. Are you kidding? Almost nobody who diets to lose we

> But the forcing factor in the weight system is net caloric balance, which is also the easiest to control. Are you kidding? Almost nobody who diets to lose weight manages to keep it off for 3 years. In the very short term (say, up to 6 months) people can control their weight via diet/exercise changes, but in the long term they generally can't. If we figured out what was going on and it turned out to be any of those other sorts of factors it would almost certainly be MUCH EASIER to control weight using those other factors than via diet and exercise.