You would, at minimum, need a new interface framing and command format; as it is, something needs to handle the SATA commands on the other end of the bus an

You would, at minimum, need a new interface framing and command format; as it is, something needs to handle the SATA commands on the other end of the bus and translate them to operate the flash. This would likely require new interface ICs on motherboards and PCI cards to handle this, either that, or you run everything over USB3.0 (which is only 5GB/s).