5 ms·

I have never done ketamine. But a hit of MDMA was kind of instrumental in lifting me out of twenty years of depression.

comrh 12y ago
Which is interesting because of the SSRI I'm on all MDMA did was make me grind my teeth really bad. I want to try it again but don't want to stop the SSRI to do so.
- ripter 12y ago
  From my understanding, SSRI's negate the effects of MDMA. So you can't do both. https://www.erowid.org/chemicals/mdma/mdma_info9.shtml https://www.erowid.org/chemicals/mdma/mdma_info9.shtml
- crystaln 12y ago
  This can also cause serotonin syndrome, which can cause serious damage to your brain and untreatable side effects. Not a safe combination.
- ChristianBundy 12y ago
  Using MDMA and and SSRI together is a bad combination. https://www.erowid.org/chemicals/mdma/mdma_info9.shtml https://www.erowid.org/chemicals/mdma/mdma_info9.shtml
- amckenna 12y ago
  You took MDMA while on an SSRI? You really should research a drug's mechanism of action and how multiple drugs may interact before taking them together. Im not a medical professional, I just want to give you a quick overview so you don't repeat that mistake. Do your own research. - An SSRI (Selective Serotonin Re-uptake Inhibitor) blocks your brain's re-uptake of serotonin and effectively increases your brain's levels of serotonin.[1] - MDMA acts as a presynaptic releasing agent of serotonin. Increasing the amount of serotonin in the synaptic cleft (space between neurons).[2] - That means the two of these drugs combined can cause a huge spike in serotonin and potentially lead to serotonin syndrome (toxicity). Be safe. [1] https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... [2] https://en.wikipedia.org/wiki/MDMA https://en.wikipedia.org/wiki/MDMA
- egypturnash 12y ago
  I was never on a SSRI for my depression. For many reasons, the biggest one being that I was way too broke to see a doctor and get a prescription during a lot of that point in my life, never mind pay for it.

comrh 12y ago

Which is interesting because of the SSRI I'm on all MDMA did was make me grind my teeth really bad. I want to try it again but don't want to stop the SSRI to do so.

ripter 12y ago
From my understanding, SSRI's negate the effects of MDMA. So you can't do both. https://www.erowid.org/chemicals/mdma/mdma_info9.shtml https://www.erowid.org/chemicals/mdma/mdma_info9.shtml
crystaln 12y ago
This can also cause serotonin syndrome, which can cause serious damage to your brain and untreatable side effects. Not a safe combination.
ChristianBundy 12y ago
Using MDMA and and SSRI together is a bad combination. https://www.erowid.org/chemicals/mdma/mdma_info9.shtml https://www.erowid.org/chemicals/mdma/mdma_info9.shtml
amckenna 12y ago
You took MDMA while on an SSRI? You really should research a drug's mechanism of action and how multiple drugs may interact before taking them together. Im not a medical professional, I just want to give you a quick overview so you don't repeat that mistake. Do your own research. - An SSRI (Selective Serotonin Re-uptake Inhibitor) blocks your brain's re-uptake of serotonin and effectively increases your brain's levels of serotonin.[1] - MDMA acts as a presynaptic releasing agent of serotonin. Increasing the amount of serotonin in the synaptic cleft (space between neurons).[2] - That means the two of these drugs combined can cause a huge spike in serotonin and potentially lead to serotonin syndrome (toxicity). Be safe. [1] https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... [2] https://en.wikipedia.org/wiki/MDMA https://en.wikipedia.org/wiki/MDMA
egypturnash 12y ago
I was never on a SSRI for my depression. For many reasons, the biggest one being that I was way too broke to see a doctor and get a prescription during a lot of that point in my life, never mind pay for it.