Yes Route53 provides a fantastic service. Just make sure you setup billing alerts to ensure you're not caught out by exceptional traffic. One of the advantage

Yes Route53 provides a fantastic service. Just make sure you setup billing alerts to ensure you're not caught out by exceptional traffic. One of the advantages of Route53 is that each domain gets its own "random" nameserver, so if you host 50+ domains they're unlikely to all be affected by a DoS attack. I wrap Route53 with git to keep history and allow quick updates over at https://dns-api.com/ https://dns-api.com/ but even if you use their control panel manually, rather than any of the APIs their service is exceptionally good.