I do on my (Windows) work laptop, because the company that owns it justifiably insists I do. It's completely transparent, except for the odd days where an upgra

I do on my (Windows) work laptop, because the company that owns it justifiably insists I do. It's completely transparent, except for the odd days where an upgrade to VirtualBox or VMPlayer will introduce new "hardening" features, that the AV software will happily flag as a terrible threat.