Why don't you take some time and do a quick and dirty prototype with all three of those solutions, and see which ones you like working with? I'd also say that

Why don't you take some time and do a quick and dirty prototype with all three of those solutions, and see which ones you like working with? I'd also say that you should probably be willing to take your first few software developer hires into acconut - if you find the right developer, but they are a Python/Flask developer, that doesn't mean you should rule them out.