The specific reason they gave was "questionable religious content", and none of the religious themes were toned down in the remake. http://www.gameinformer.com

The specific reason they gave was "questionable religious content", and none of the religious themes were toned down in the remake. http://www.gameinformer.com/b/news/archive/2012/02/29/binding-of-isaac-blocked-from-3ds-due-to-quot-questionable-religious-content-quot.aspx http://www.gameinformer.com/b/news/archive/2012/02/29/bindin...