Cython, numba, and other projects do this for a subset of the language, but you lose the metaprogramming that makes things like SQLAlchemy possible. You also ha

Cython, numba, and other projects do this for a subset of the language, but you lose the metaprogramming that makes things like SQLAlchemy possible. You also have to treat most user objects as hashmaps and constantly look up their fields since members can be added or redefined at any time.