Having multiple system package managers coexisting is pretty thorny. If very carefully delineated so they manage completely independent bits of software install

Having multiple system package managers coexisting is pretty thorny. If very carefully delineated so they manage completely independent bits of software installed in their own prefixes, I could see it working (with some careful path management). But if you're actually installing/upgrading system software with it, having some mix of apt, rpm, and guix managing your packages sounds like a recipe for pain.