This is a very important point that seems to be forgotten frequently. Particularly when doing methodological comparison between disciplines. The other point is

This is a very important point that seems to be forgotten frequently. Particularly when doing methodological comparison between disciplines. The other point is complexity. The number of variables needed to create a useful model of a jet engine is a lot smaller than the number needed to model an organic system. This means that today we have useful models of jet engines and we can reliably test something with simulations - we may generate loads of valid data and easily apply "top-notch" statistics. The same, unfortunately, is not true for medicine.