The important point of Dave's screed is at the bottom (and it's something every single person who has ever worked in VC and made the jump to the light side says

The important point of Dave's screed is at the bottom (and it's something every single person who has ever worked in VC and made the jump to the light side says this): for your first company, don't hold on too long - it's OK to sell out. Successfully selling out makes it ridiculously easy to raise money, strike partnerships, and do things your way the second time around. Hell, it probably gets you a third bite at the apple as well.