This paper has a lot of misleading information that I don't have time to parse out at the moment. I'm relatively well versed in aging literature, and right off

This paper has a lot of misleading information that I don't have time to parse out at the moment. I'm relatively well versed in aging literature, and right off the bat, citing the SENS hypothesis before anything a bit more validated by data leaves a bad taste in my mouth. For a thorough overview of why aging happens, and how we may target it with therapeutics, may I suggest this excellent paper highlighted in Cell Press' "Best of 2013."(Full Text is free!) Hallmarks of Aging - http://www.cell.com/cell/pdf/S0092-8674(13)00645-4.pdf http://www.cell.com/cell/pdf/S0092-8674(13)00645-4.pdf If you're interested particularly in the forefront of rejuvinative biology, may I suggest a few more amazing papers. Aging and reprogramming: a two way street Anne Brunet's group at Stanford. tl;dr - Pluripotent reprogramming (see Yamanaka 2006) reverses many molecular signals of aging http://web.stanford.edu/group/brunet/Mahmoudi%20et%20al%202012.pdf http://web.stanford.edu/group/brunet/Mahmoudi%20et%20al%2020... Several of the recent parabiosis papers, from the labs of Amy Wagers & Lee Rubin at Harvard, and Saul Villeda at UC - San Francisco --Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html --Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle http://www.sciencemag.org/content/344/6184/649.abstract http://www.sciencemag.org/content/344/6184/649.abstract --Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors http://www.sciencemag.org/content/344/6184/630.abstract http://www.sciencemag.org/content/344/6184/630.abstract