> They are using the yogurt rule Ahh, you mentioned Autism spectrum, so I assumed that couldn't be the case. > we have metagenomics on them (v4 rDNA sequence

> They are using the yogurt rule Ahh, you mentioned Autism spectrum, so I assumed that couldn't be the case. > we have metagenomics on them (v4 rDNA sequence reads) not full seq data There is plenty of genomic data beyond 16S. For the HMP, full sequencing of selected strains as well as hundreds of WGS metagenomes were done. And that's almost old news now, I'm sure there is even more being done currently. The result is basically either a full genome, or a set of giant chunks of the genome of the abundant microbes there. We don’t have all the genomes closed (although some are in the process!) but closing a genome is a very high bar and probably not worth it when you can get a lot of data from a fairly good set of large contigs. Can the assemblies be chimeric/wrong/whatever? sure, some of them will be, but at this point most assemblies are fairly good :)