I use gnus. On my desktop I run offlineimap+fastmail, on my laptop I just use fastmail directly. Gnus is great for reading/posting to Gmane newsgroups, I would

I use gnus. On my desktop I run offlineimap+fastmail, on my laptop I just use fastmail directly. Gnus is great for reading/posting to Gmane newsgroups, I would use it for that even if I switched to something else for reading email. For plain mail reading it actually could be a lot better. For example, support for seeing your own replies in a thread is a bit flaky (notmuch.el is better for that), and since Emacs is single-threaded, sending large attachments blocks it (perhaps I should use that relay trick from the article, but then it's not often I use email for sharing big files).