If I was writing line of business software these days, I'd either go the web route and use JavaScript and HTML 5, or if it was something that preferred to live

If I was writing line of business software these days, I'd either go the web route and use JavaScript and HTML 5, or if it was something that preferred to live on the desktop, I'd use Qt. Now, if you've only heard a little bit about Qt, you might be tempted to think you only need it if you need cross-platform, but in my experience it's actually better than any of the Microsoft frameworks even purely on Windows. (A simple test: write a Hello World program in Winforms, WPF and Qt, then try doing some simple drag operations with the mouse, moving the window around, resizing it. Last I tried, Qt was the only one that updated the window correctly, without flicker. This remained true even after I tried the recommended solutions in Winforms and WPF to reduce flicker.) The fact that Qt gives you the option of going cross-platform if you ever need it in the future is just a nice bonus.