2 ms·
The study didn't show that the treatment cured the infection. It just found that bowel movements decreased, and patient self-rated health increased. The placebo
by cpncrunch 12y ago
The study didn't show that the treatment cured the infection. It just found that bowel movements decreased, and patient self-rated health increased. The placebo effect has been shown to have a significant effect on diarrhea for IBS:
http://www.webmd.com/ibs/news/20101221/secrecy-may-be-unnecessary-for-placebo-effect http://www.webmd.com/ibs/news/20101221/secrecy-may-be-unnece...
Also, there are currently no RCTs showing the effectiveness of fecal transplant for C difficile, and a Nature review cautions that there will be a strong placebo effect for invasive procedures:
http://tcminfection.com/pdf/5%20(119).pdf http://tcminfection.com/pdf/5%20(119).pdf
(This particular study isn't invasive, but it is highly novel, and that has also been shown to correlate with a large placebo effect).
- refurb 12y agoI didn't look into the details of this particular trial, so if in fact it did just look at patient self-rated health then yes, placebo effect could be a big factor. I have seen other open-label uncontrolled studies for fecal transplant that had some pretty spectacular outcomes. Is such a trial as rigorous as a RCT? No, but it's a pretty positive signal.
- cpncrunch 12y agoAlso, here is the full-text of this study: http://jama.jamanetwork.com/article.aspx?articleid=1916296 http://jama.jamanetwork.com/article.aspx?articleid=1916296