5 ms·

I've dealt with IBS symptoms for 17 years. I would love to try one of these pills. Digestive maladies can really hamper a person's life. The digestive system is

by Klinky 12y ago

I've dealt with IBS symptoms for 17 years. I would love to try one of these pills. Digestive maladies can really hamper a person's life. The digestive system is poorly understood, and there aren't a lot of effective treatment options for IBS & IBDs like Crohn's & Ulcerative Colitis. The treatments which are effective for IBD are often invasive or can have serious side effects.

jostmey 12y ago
Second that. I would have no problem taking it.
rollthehard6 12y ago
Yes, I have relatively mild Crohn's, controlled well with LDN (Low Dose Naltrexone, 2mg daily) but I would love to try this.
- refurb 12y ago
  Any ideas on how naltrexone works for Crohn's? I have seen a few articles describing its efficacy. I'm just curious what the mechanism of action. Is it through it's mu receptor antagonism or something else?
300bps 12y ago
there aren't a lot of effective treatment options for IBS & IBDs like Crohn's & Ulcerative Colitis I had IBS from the age of 10 to the age of 30. First off I have to say that IBS is not even remotely comparable to IBD. For most people, IBS is a very inconvenient life-altering syndrome. IBD is often 100x worse, increases the risks of colon cancer and can be life threatening. I wouldn't wish ulcerative colitis or Crohn's disease (IBD) on my worst enemy. Beyond that, I'm not sure why you think this pill would help your IBS. It is specifically meant to treat one particular problem - a clostridium difficile infection. Typically the colon is populated by helpful or otherwise non-harmful bacteria. Clostridium difficile is an opportunistic infection that often takes hold after someone takes a course of antibiotics that kills all the helpful bacteria. The fecal transplant puts back the normal bacteria into your colon, attempting to crowd out the clostridium difficile bacteria. There is anecdotal evidence of fecal transplants helping IBS or IBD but it has not been studied well. Source: http://www.mayoclinic.org/medical-professionals/clinical-updates/digestive-diseases/quick-inexpensive-90-percent-cure-rate http://www.mayoclinic.org/medical-professionals/clinical-upd... I would suspect much of the benefit to IBS from a fecal transplant (or fecal transplant pill) derives from the placebo effect. After 20 years of having IBS, the best cure I found for myself was to eat a lot of dietary fiber and drink a lot of water. I haven't had symptoms of IBS for over 12 years now since doing that. Unfortunately I find I have to eat about 40 grams of dietary fiber and drink about a gallon and a half of water per day. That takes actual work, but it's worth it. Source on dietary fiber treating IBS: http://www.aboutibs.org/site/treatment/diet/dietary-fiber http://www.aboutibs.org/site/treatment/diet/dietary-fiber
- Klinky 12y ago
  Perhaps you are too distant from your experience of IBS, or your symptoms were not as severe as some, but IBS can destroy someone's life just as well as an IBD can. Someone in remission with an IBD may have better quality of life than someone with uncontrollable IBS. Severity varies by patient, and while IBDs are usually more severe, that isn't always the case. Mentioning the two together does not mean that I am indicting they are equally severe. C.diff, IBS and IBD are all ailments with the potential to be treated via fecal transplantation. The IBS issues I've dealt with have lead to some catastrophic effects. Twice after dealing with stomach flu/food poisoning I developed gastroparesis or severe gastric motility issues. I lost 60 lbs during the first bout in 2006 and 45 lbs during a second bout in 2012. My quality of life was horrible during these periods of time. I basically lost a year of my life each time. Luckily you found a solution for your IBS, many people have not. If simply upping my fiber solved the problem then I would be set, but fiber lead to more gas and pain for me. Probiotics on the market often leave me constipated and nauseated. Even if I stick to a regimen irregularities continue, and my body still seems to ebb and flow. So far regular strenuous exercise seems to help me, but IBS often leads to fatigue. This all happened to me after I went swimming in a river with friends and got ill later in the evening. I may have swallowed river water contaminated with agriculture run off. Nothing has been the same since then. This is similar to many people's stories about IBS. The hope is that the pill would restore whatever was killed off due to the initial illness, which might result in regulation and relief. Yeah it's a shot in the dark and not officially meant to treat ~anything~, but at least it's something with some promise. The doctors over the years haven't had an answer for me. Treatments are also used off label all the time and trials are often very narrow in scope to meet regulatory guidelines. Somehow I think you know this already and are being a bit of a smartass.
  - 300bps 12y ago
    From the little you've written here, it doesn't sound to me like you have typical IBS or perhaps even IBS at all. The diagnostic criteria for IBS are here: http://www.aboutibs.org/site/what-is-ibs/intro-to-ibs/diagnosis http://www.aboutibs.org/site/what-is-ibs/intro-to-ibs/diagno... Dramatic weight loss as you've outlined is a sign you're suffering from something more serious than IBS. That makes sense since you list several other non-IBS related disorders ("stomach flu (sic) / food poisoning" as well as gastroparesis). The thing that doesn't make sense to me is why you attribute these things to IBS? If simply upping my fiber solved the problem then I would be set, but fiber lead to more gas and pain for me. There is nothing "simple" about increasing your fiber in a manner to solve IBS. As I mentioned in my original comment, it takes actual work. First, you have to eschew eating anything at all throughout the day that doesn't have dietary fiber. Second, you must gradually increase your fiber intake over a period of a year to avoid gas buildup and pain. Third, you must actively seek out fiber rich foods to eat throughout the day. As I said, there is absolutely nothing simple about it. This all happened to me after I went swimming in a river with friends and got ill later in the evening. Again, I'm questioning why you think this has anything to do with IBS. You don't catch IBS by swimming in a river.
justifier 12y ago
i think the taboo of talking about our shit is one of the main obstacles we face currently in the dialogue on personal and public health because of this public silence i thought for the longest time that the way i shit was just the way all people shit: a roulette roller coaster ride through the whole bristol stool scale once i removed wheat flour from my diet and began eating a quinoa`oatmeal hybrid everything changed for the better it has to be tricolor quinoa because the three colors: white, red, and black; all burst at different rates when boiled what you want is the whites to be fully popped, some reds to be beginning to pop and the blacks unpopped to pass through you like diamonds on a drill bit cook the quinoa, then drop in an equal dose of oatmeal with some water and stir until the oatmeal is as soft as you like it oatmeal alone is a poor rice substitute, but the mix gives a texture that makes the combination a perfect substitute for any meal where you might use rice my body has since thanked me in all those wondrous popsci ways: more energy, better focus, less irratibility i feel better and the difference was noticeable in days

by Klinky 12y ago

jostmey 12y ago

Second that. I would have no problem taking it.

rollthehard6 12y ago

Yes, I have relatively mild Crohn's, controlled well with LDN (Low Dose Naltrexone, 2mg daily) but I would love to try this.

refurb 12y ago
Any ideas on how naltrexone works for Crohn's? I have seen a few articles describing its efficacy. I'm just curious what the mechanism of action. Is it through it's mu receptor antagonism or something else?

300bps 12y ago

there aren't a lot of effective treatment options for IBS & IBDs like Crohn's & Ulcerative Colitis I had IBS from the age of 10 to the age of 30. First off I have to say that IBS is not even remotely comparable to IBD. For most people, IBS is a very inconvenient life-altering syndrome. IBD is often 100x worse, increases the risks of colon cancer and can be life threatening. I wouldn't wish ulcerative colitis or Crohn's disease (IBD) on my worst enemy. Beyond that, I'm not sure why you think this pill would help your IBS. It is specifically meant to treat one particular problem - a clostridium difficile infection. Typically the colon is populated by helpful or otherwise non-harmful bacteria. Clostridium difficile is an opportunistic infection that often takes hold after someone takes a course of antibiotics that kills all the helpful bacteria. The fecal transplant puts back the normal bacteria into your colon, attempting to crowd out the clostridium difficile bacteria. There is anecdotal evidence of fecal transplants helping IBS or IBD but it has not been studied well. Source: http://www.mayoclinic.org/medical-professionals/clinical-updates/digestive-diseases/quick-inexpensive-90-percent-cure-rate http://www.mayoclinic.org/medical-professionals/clinical-upd... I would suspect much of the benefit to IBS from a fecal transplant (or fecal transplant pill) derives from the placebo effect. After 20 years of having IBS, the best cure I found for myself was to eat a lot of dietary fiber and drink a lot of water. I haven't had symptoms of IBS for over 12 years now since doing that. Unfortunately I find I have to eat about 40 grams of dietary fiber and drink about a gallon and a half of water per day. That takes actual work, but it's worth it. Source on dietary fiber treating IBS: http://www.aboutibs.org/site/treatment/diet/dietary-fiber http://www.aboutibs.org/site/treatment/diet/dietary-fiber

Klinky 12y ago
Perhaps you are too distant from your experience of IBS, or your symptoms were not as severe as some, but IBS can destroy someone's life just as well as an IBD can. Someone in remission with an IBD may have better quality of life than someone with uncontrollable IBS. Severity varies by patient, and while IBDs are usually more severe, that isn't always the case. Mentioning the two together does not mean that I am indicting they are equally severe. C.diff, IBS and IBD are all ailments with the potential to be treated via fecal transplantation. The IBS issues I've dealt with have lead to some catastrophic effects. Twice after dealing with stomach flu/food poisoning I developed gastroparesis or severe gastric motility issues. I lost 60 lbs during the first bout in 2006 and 45 lbs during a second bout in 2012. My quality of life was horrible during these periods of time. I basically lost a year of my life each time. Luckily you found a solution for your IBS, many people have not. If simply upping my fiber solved the problem then I would be set, but fiber lead to more gas and pain for me. Probiotics on the market often leave me constipated and nauseated. Even if I stick to a regimen irregularities continue, and my body still seems to ebb and flow. So far regular strenuous exercise seems to help me, but IBS often leads to fatigue. This all happened to me after I went swimming in a river with friends and got ill later in the evening. I may have swallowed river water contaminated with agriculture run off. Nothing has been the same since then. This is similar to many people's stories about IBS. The hope is that the pill would restore whatever was killed off due to the initial illness, which might result in regulation and relief. Yeah it's a shot in the dark and not officially meant to treat ~anything~, but at least it's something with some promise. The doctors over the years haven't had an answer for me. Treatments are also used off label all the time and trials are often very narrow in scope to meet regulatory guidelines. Somehow I think you know this already and are being a bit of a smartass.
- 300bps 12y ago
  From the little you've written here, it doesn't sound to me like you have typical IBS or perhaps even IBS at all. The diagnostic criteria for IBS are here: http://www.aboutibs.org/site/what-is-ibs/intro-to-ibs/diagnosis http://www.aboutibs.org/site/what-is-ibs/intro-to-ibs/diagno... Dramatic weight loss as you've outlined is a sign you're suffering from something more serious than IBS. That makes sense since you list several other non-IBS related disorders ("stomach flu (sic) / food poisoning" as well as gastroparesis). The thing that doesn't make sense to me is why you attribute these things to IBS? If simply upping my fiber solved the problem then I would be set, but fiber lead to more gas and pain for me. There is nothing "simple" about increasing your fiber in a manner to solve IBS. As I mentioned in my original comment, it takes actual work. First, you have to eschew eating anything at all throughout the day that doesn't have dietary fiber. Second, you must gradually increase your fiber intake over a period of a year to avoid gas buildup and pain. Third, you must actively seek out fiber rich foods to eat throughout the day. As I said, there is absolutely nothing simple about it. This all happened to me after I went swimming in a river with friends and got ill later in the evening. Again, I'm questioning why you think this has anything to do with IBS. You don't catch IBS by swimming in a river.

justifier 12y ago

i think the taboo of talking about our shit is one of the main obstacles we face currently in the dialogue on personal and public health because of this public silence i thought for the longest time that the way i shit was just the way all people shit: a roulette roller coaster ride through the whole bristol stool scale once i removed wheat flour from my diet and began eating a quinoa`oatmeal hybrid everything changed for the better it has to be tricolor quinoa because the three colors: white, red, and black; all burst at different rates when boiled what you want is the whites to be fully popped, some reds to be beginning to pop and the blacks unpopped to pass through you like diamonds on a drill bit cook the quinoa, then drop in an equal dose of oatmeal with some water and stir until the oatmeal is as soft as you like it oatmeal alone is a poor rice substitute, but the mix gives a texture that makes the combination a perfect substitute for any meal where you might use rice my body has since thanked me in all those wondrous popsci ways: more energy, better focus, less irratibility i feel better and the difference was noticeable in days