From a purely technical perspective, you probably can't go wrong with any of the three unless you have super specific needs. In cases like that, you may not eve

From a purely technical perspective, you probably can't go wrong with any of the three unless you have super specific needs. In cases like that, you may not even want to use Python at all. The best way to decide which to use is to take your team and hammer out some quick project using your 2-3 leading framework candidates. Whichever your team is more subjectively happy with is where you should go. There are other considerations, but so many projects fail to gain traction after taking longer than planned to launch. Team productivity is priority #1 for us, though subjectively we've found it to be very easy to find contractors who can be plugged into a Django project with minimal ramp-up.