A couple quick notes here further to your point: the effective dose for melatonin seems to be around 250mcg, while most supplements are sold at 1, 3, or 5mg. Th

A couple quick notes here further to your point: the effective dose for melatonin seems to be around 250mcg, while most supplements are sold at 1, 3, or 5mg. There is no evidence of melatonin losing effectiveness over time that I'm aware of, but there is some evidence that larger doses are less effective than 250mcg. Try splitting your pills or titrating your liquids and see how it works for you. Source: sorry, on mobile and just taking a quick break, this information has appeared in other discussions on HN though, and should be googlable.