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At times I inexplicably wake at 2am no matter how tired I am. After three nights of this I will start taking a single Melatonin tablet before bed. This works an
by happyscrappy 12y ago
At times I inexplicably wake at 2am no matter how tired I am. After three nights of this I will start taking a single Melatonin tablet before bed. This works and I stop after a week and then generally go many months before it starts again. If I kept using Melatonin it would certainly lose its efficacy.
- krrrh 12y agoA couple quick notes here further to your point: the effective dose for melatonin seems to be around 250mcg, while most supplements are sold at 1, 3, or 5mg. There is no evidence of melatonin losing effectiveness over time that I'm aware of, but there is some evidence that larger doses are less effective than 250mcg. Try splitting your pills or titrating your liquids and see how it works for you. Source: sorry, on mobile and just taking a quick break, this information has appeared in other discussions on HN though, and should be googlable.
- wahnfrieden 12y agoYou can buy Melatonin pills in 300mcg amounts, see Amazon.