3 ms·
I've never seen an explanation for why APOE1 is rare to non-existent. I feel like understanding that may give useful clues to the larger Alzheimer's question. D
by cariaso 12y ago
I've never seen an explanation for why APOE1 is rare to non-existent. I feel like understanding that may give useful clues to the larger Alzheimer's question. Do you have any insight? While the population frequency of heterozgosity for the 2 relevant SNPs
* http://snpedia.com/index.php/Rs429358 http://snpedia.com/index.php/Rs429358
* http://snpedia.com/index.php/Rs7412 http://snpedia.com/index.php/Rs7412
is low, but not low enough to justify the near total absence of E1/E1.
- pcrh 12y agoA name is just a name. There are about 20 varieties of apoE, most of which are extremely rare, i.e. found in only a handful of families. ApoE1 is simply rare, and not really relevant to Alzheimer's disease, although it does affect blood cholesterol levels. http://www.ncbi.nlm.nih.gov/pubmed/?term=22859420 http://www.ncbi.nlm.nih.gov/pubmed/?term=22859420
- pcrh 12y agoBy the way, I see you maintain SNPedia, thanks! The apoE1 snp is Rs121918394