I wonder how one differentiates the possibility that exceptional individuals are alienated from others around them by their exceptionality from the possibility

I wonder how one differentiates the possibility that exceptional individuals are alienated from others around them by their exceptionality from the possibility that exceptional mental ability is intrinsically accompanied either directly by social difficulties or by social development that is less resilient to negative aspects in one's upbringing. I suspect that both of these happen to some degree, but they seem difficult to disentangle.