I'm not sure there's a meaningful distinction there. Caffeine is the (current) end product of an evolutionary process. If we went out and killed every caffeine-

I'm not sure there's a meaningful distinction there. Caffeine is the (current) end product of an evolutionary process. If we went out and killed every caffeine-producing plant in existence today but continued to synthesize caffeine ourselves, caffeine would still be a product of evolution and would still exist, despite the fact that its "reproduction strategy" has changed from "biosynthesis by plants" to "industrial synthesis by humans", and that its continued existence is mediated by memes, not genes.