I've been a big fan of Bootstrap since V2 - have used it on over 10 websites from Wordpress to completely custom. I think it's more of a matter of what you use

I've been a big fan of Bootstrap since V2 - have used it on over 10 websites from Wordpress to completely custom. I think it's more of a matter of what you use first and get ust to; at this point, both are pretty similar to each other and any gaps can be filled in with additional jQuery plugins. Lately, I've been using a grid from unsemantic.com - it has 20 divisions based on a grid-5 system and supports back to IE7 which some of my clients require - I roll that with bootstraps JS file for good results, but even that has fallen short sometimes - needing to add a grid-49 and a grid-2 to get layouts just right. All of them continue to fall short though - requiring multiple media queries in my css file to account for various screen sizes for a pixel perfect layout causing me to consider rolling my own. Which in the end means; there is no perfect grid system. You either use an existing one and work around the limitations, or don't use one and do more work from scratch.