You're right re: large numbers of small-effect variants - and it's also true for other genetically determined traits (such as cholesterol levels). Now, there ar

You're right re: large numbers of small-effect variants - and it's also true for other genetically determined traits (such as cholesterol levels). Now, there are some high-impact, low-frequency variants in the non-behavioral sciences, but so long as they work additively (and generally are not recessive traits) they usually get picked up in the GWAS anyway. Obliquely, this leads me to argue that you may well find great drug targets among the behavioral genetics GWAS hits (for certain traits).