For what it's worth, here is a (bleeding edge) way to run Django with Twisted: http://clemesha.org/blog/2009/apr/23/Django-on-Twisted-using-latest-twisted-web-w

For what it's worth, here is a (bleeding edge) way to run Django with Twisted: http://clemesha.org/blog/2009/apr/23/Django-on-Twisted-using-latest-twisted-web-wsgi http://clemesha.org/blog/2009/apr/23/Django-on-Twisted-using.... Full working example code is linked from the article. With this you get the benefit of being self-contained and you get Django with all it's joys plus Twisted for your long-polling, etc.