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Chemists Uncover Powerful New Click Chemistry Reactivity
- lancerpickens 12y agoTime will tell. Major downside of the CuAAC click reaction is using azides, which are hella dangerous.
- dnautics 12y agoAlkyl azides are not very dangerous.
- jamesash 12y agoPretty breathless PR piece from Scripps that actually doesn't go into any notable detail on the chemical reaction, hits all the buzzwords (green, click, yada yada) and manages to spell sulfur "sulfer" and hydrolyze "hydrolize". (Here's an actually awesome recent piece of Scripps science)[http://openflask.blogspot.com/2013/08/ingenol-behind-scenes.html http://openflask.blogspot.com/2013/08/ingenol-behind-scenes....].
- dbcooper 12y agoDerek Lowe covered this here: http://pipeline.corante.com/archives/2014/08/13/sulfates_and_what_they_can_make.php http://pipeline.corante.com/archives/2014/08/13/sulfates_and...
- cageface 12y agoI was in Professor Sharpless' organic synthesis class at Scripps many many years ago. Very nice guy and extremely bright. I'm not surprised he's pushing the envelope again.
- hga 12y agoYeah, Professor Sharpless. I took Organic II from him, he was indeed "very nice and extremely bright" (I had no doubt he'd get a Nobel in due course, as he did), and I too am not surprised. Here's Wikipedia on Click chemistry, which says he coined the phrase: https://en.wikipedia.org/wiki/Click_chemistry https://en.wikipedia.org/wiki/Click_chemistry Anecdote: he dipped some absorbent paper in safrole and had us pass them around and smell them, and in the middle of this said something to the effect, "Oh, BTW, this is officially carcinogenic, but it's not truly dangerous, I wouldn't have you smelling it if it was". As a former fan of root beer before the FDA forced it's removal I appreciated that. As the son of a Cajun mother I'm really glad filé powder contains doesn't contain it, banning it would be even more criminal.
- dnautics 12y agoClick chemistry despite its cool sounding name isn't very useful because the clickable parts that are left behind in the final structure are not necessarily themselves useful for other things..m in biology this can often mean "they get in the way" except for a subset of problems like payload attachment or imaging agent/analytical agent attachment. Mostly click chemistry gets used to make other biological discovery marginally easier.