4 ms·
The CEA is useful for prognosis, staging and follow up. It is useless for diagnosis. "The CEA test has a specificity of between 30-80% and it is not recommende
by seesomesense 12y ago
The CEA is useful for prognosis, staging and follow up.
It is useless for diagnosis.
"The CEA test has a specificity of between 30-80% and it is not recommended by the National Institute for Health and Clinical Excellence (NICE) for the diagnosis of early colorectal cancer" http://www.patient.co.uk/doctor/carcinoembryonic-antigen-cea http://www.patient.co.uk/doctor/carcinoembryonic-antigen-cea
Causes of false postive CEA include but are not confined to:
"Inflammatory Bowel Disease.
Pancreatitis.
Liver disease.
Tobacco use can lead to elevated CEA levels. (CEA is elevated in 19% of smokers and only 3% of the non-smoking healthy population.)
Diverticulitis.
Hepatitis.
Peptic ulcers.
Hypothyroidism.
Cirrhosis of the liver.
COPD.
Lung infection.
Pleural effusions.
Biliary obstruction.
Treatment with oral 5-FU.
High serum glutamic-pyruvic transaminase (sGPT) levels.
Non-malignant liver disease, including cirrhosis, chronic active hepatitis.[6]
Chronic kidney disease.
Pancreatic disease.[7]
Inflammatory bowel disease, diverticulitis, irritable bowel syndrome.
Respiratory diseases, eg pleural inflammation, pneumonia.
Smoking.
Ageing.[8]
Atherosclerosis
"http://www.kantrowitz.com/cancerpoints/tumormarkerfalsepositives.html http://www.kantrowitz.com/cancerpoints/tumormarkerfalseposit...
- clarkevans 12y agoGosh : many of these are just as scary. Wouldn't it still be useful to have the screen taken, compare it with previous years, and see if anything changed? If you've got a change, then, you could start asking why?
- salgernon 12y agoThis was my thinking exactly. These are data points and while the test itself in isolation may not be conclusive, when combined with other factors that may be measured, inferred or analyzed as trends over time, this may have had me tested years ago. Standard for colonoscopy screening is to start at age 50. I'm 44.