Indeed. Wording is important. I meant that the known mechanism that you have mentioned does not explain all its reported benefits. Specifically in the anti-inf

Indeed. Wording is important. I meant that the known mechanism that you have mentioned does not explain all its reported benefits. Specifically in the anti-inflammatory effect, it seems like inhibition of prostaglandin synthesis (via COX enzyme binding) is not the reason[1]. As aspirin has so many potential benefits, it seems to me that it has to have some effect in some very basic and common site and the mitochondrial respiratory chain is a good, if not best, candidate. If you are interested in uncoupling and free radical production, Peter[2] has a good amount of info about it. At any rate, aspirin has many knowns unkowns; that´s what I meant in my original post. [1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213311/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213311/ [2] http://high-fat-nutrition.blogspot.com.es/ http://high-fat-nutrition.blogspot.com.es/