The USPSTF recommendation in your link is from 2007, so it may perhaps be out of date. Also, the recent study directly challenges the USPSTF position [1]: "Th

The USPSTF recommendation in your link is from 2007, so it may perhaps be out of date. Also, the recent study directly challenges the USPSTF position [1]: "The US Preventive Services Task Force (USPSTF) have reported on benefits and harms of aspirin use for prevention of specific diseases like colorectal cancer (CRC) and cardiovascular disease (CVD). However, they have not investigated overall benefits and harms based on all major diseases." I assume the figure of 130,000 lives saved over 20 years takes into account the increased risk of intestinal bleeding and stroke. [1] http://annonc.oxfordjournals.org/content/early/2014/07/30/annonc.mdu225.full http://annonc.oxfordjournals.org/content/early/2014/07/30/an...