tl;dr: It seems inevitable that any group of humans too long cut off from the majority of humanity is destined for destruction once contact is re-established d

tl;dr: It seems inevitable that any group of humans too long cut off from the majority of humanity is destined for destruction once contact is re-established due to cultural shock, unscrupulous or illegal activity, but chiefly by diseases against which they have no natural immunity. Second: a bunch of formerly uncontacted people have been interviewed after contact was made and none of them indicated a desire to abstain from the evil outside world or to preserve their way of life... They were merely afraid and/or lacked appropriate opportunity for contact. Further, none of them were wholly unaware of life outside their small isolated villages/reserves; people gossip and even the most isolated peoples have some knowledge of the rest of humanity. Best we can tell this process is inevitable. The article has some suggestions for minimizing the damage but by and large there is little anyone can do despite the best intentions unless we were to forcibly isolate these people and prohibit them from making contact.