Alcohol blocks absorption of B1-B6 (due to preferential metabolism) but it doesn't deplete your body of vitamin B (and your body's stores of vitamin B may last

Alcohol blocks absorption of B1-B6 (due to preferential metabolism) but it doesn't deplete your body of vitamin B (and your body's stores of vitamin B may last months so you're unlikely to run out during your hangover). As long as you're not permanently drunk (i.e. an alcoholic), vitamin deficiency probably won't be an issue. If you're not deficient in a vitamin, taking additional doses probably won't give any benefit. Belief in vitamin B helping with hangovers usually leads back to this study: http://www.ncbi.nlm.nih.gov/pubmed/4588294 http://www.ncbi.nlm.nih.gov/pubmed/4588294 but I wouldn't personally put much trust in studies from the 1970's about Pyritinol (B6) preventing hangovers. Subsequent studies have failed to reproduce the results. And large unnecessary doses of Pyritinol may lead to cholestatic hepatitis and other issues so exercise caution.