It depends on what you are making I think. If you are making a website, a site like Youtube lets say, where the goal is to have as many people use it as possibl

It depends on what you are making I think. If you are making a website, a site like Youtube lets say, where the goal is to have as many people use it as possible it would make sense for you to have it work with a variety of limitations that users might have. If you are creating a very specific SAAS then you are probably able to convince many users to run javascript if they get something good back for it. In the end, if you are willing to pay $50/month for something, you might also be willing to enable JS, while if you are visiting a random website that doesn't work without JS you might think 'never mind, I don't need this'.