Wouldn't it depend on the type of audience you're trying to appeal to? I would imagine the amount of people disabling JS would be a lot more coming from a site

Wouldn't it depend on the type of audience you're trying to appeal to? I would imagine the amount of people disabling JS would be a lot more coming from a site like HN, compared to say, pintrest. It would be worth making sure your site functions without JS if you know a lot of your audience will be disabling JS.