Node.js is the answer, here. Most stuff you do on the client (outside webgl and game calculations) shouldn't be impacted heavily by these kinds of optimization

Node.js is the answer, here. Most stuff you do on the client (outside webgl and game calculations) shouldn't be impacted heavily by these kinds of optimization snafus. But if you're trying to get your server to be as performant as possible, these can really kill you if you snafu naïvely.